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CHEMICAL
STRUCTURE-BIOLOGICAL ACTIVITY: QUANTITATIVE APPROACHES
Praha
(Czechoslovakia), June 27-29, 1973
Proceedings "Quantitative Structure-Activity Relationships" (M. Tichý, ed.), Akadémiai
Kiadó, Budapest, Birkhäuser Verlag, Basel und Stuttgart (as Experientia Suppl.
No. 23) 1976
Organising
committee: A.David, M. Tichý (secretary general), K. Bocek, J. Kopecký, R.
Zahradník
- Sections (chairs):
 |
Mathematical
empirical models of Free-Wilson type, four-parameter equation and related
topics, Hansch approach (J.K. Seydel, Z. Roth) |
|
Statistical
approaches of fitting models (R. Franke, V. Trcka) |
|
Correlations
between various physico-chemical properties and biological activities (W.P.Purcell,
J. Kopecký) |
|
Correlations
between electronic indices from molecular orbital calculations and
biological activities (R. Zahradník, L. Vrbovský) |
|
Discussion
of the most significant characteristics used in the correlations in terms of
a theoretical approach (L.B. Kier, M. Kuchar) |
-
- From introduction of the Lemont B. Kier lecture:
- "In
this beautiful city of Prague, there is a street Zlatá ulicka where once lived
men who sought to change base substances into gold. Their belief in a successful
transformation was based upon their contemporary understanding of the properties
of substances familiar to them. We must judge their success not on the amount of
gold they produced, but on the contributions to science made by their efforts. Today
also, scientists seek to change innocuous matter into the gold of effective,
safe drugs. Their rationale is also based upon their understanding of the
properties of molecules, both chemical and biological. In addition to new drugs,
there is a large contribution from these efforts to understanding
structure-activity relationships. These scientists are also members of the Zlatá
ulicka society."
Scientific committee formed ad hoc during the symposium: W.P.Purcell (speaker), V.A.
Filov, R. Franke, L.B. Kier, P.A. Kollman, J.K. Seydel.
In
the concluding remarks, the committee drew attention to the following points:
|
QSAR
should be considered as one of the tools providing a better understanding of
processes taking place in living organisms, which may in the long run result
in the ability to predict biological activities of compounds |
|
one
must be aware not only of limitations of this approach but also of the
limitations of the statistical analysis used and should not therefore attach
exaggerated importance to the results obtained |
|
because
of their complementary nature, both molecular orbital calculations and
physico-chemical experiments should be employed |
|
such
meetings as this one organised in Praha should have a continuation. The
committee recommended to start a series of QSAR symposia |
Contributors:
| Allievi
G (Italy) |
Duax
W.L. (USA) |
Kuchar
M. (CZ) |
Roubal
Z. (CZ) |
| Augustin
J. (CZ) |
Fernandez-Alonso
J.I. (Spain) |
Kulkarni
V.M. (India) |
Sabin
J.R. (USA) |
| Ažman
A. (Yugoslavia) |
Filov
V.A. (USSR) |
Lancini
G. (Italy) |
Šafanda
J. (CZ) |
| Berkoff
C.E. (USA) |
Franke
R. (GDR) |
Lukovits
I. (Hungary) |
Schaper
K.J. FRG) |
| Biszó
G. (Hungary) |
Gallo
G.G. (Italy) |
Murray
W.J. (USA) |
Seydel
J.K. (FRG) |
| Bláha
K. sr. (CZ) |
Giannini
D.G. (USA) |
Náray-Szabó
G. (Hungary) |
Slanina
Z. (CZ) |
| Bocek
K. (CZ) |
Goodford
P.J. (England) |
Nemec
P. (CZ) |
Sobotka
P. (CZ) |
| Brunová
B. (CZ) |
Grimme
L.H. (FRG) |
Nemecek
O. (CZ) |
Sova
J. (CZ) |
| Catalán
J. (Spain) |
Hansch
C. (USA) |
Norrington
F.E. (England) |
Tichý
M. (CZ) |
| Celadník
M. (CZ) |
Havlík
I. (CZ) |
Nuss
M.E. (USA) |
Tipnis
H.P. (India) |
| Collett
J.H. (England) |
Harris
R.L.N. (Australia) |
Palát
K. (CZ) |
Tomlinson
E. (England) |
| Cramer
R.D. (USA) |
Hobza
P. (CZ) |
Pataki
I. (Hungary) |
Trcka
V. (CZ) |
| Dearden
J.C. (England) |
Janku
I. (CZ) |
Pelizza
G. (Italy) |
Trinajstic
N. (Yugoslavia) |
| Devia
A. (Spain) |
Joyner
J.C. (USA) |
Ponce
C.A. (Argentine) |
Vrbovský
L. (CZ) |
| Dittmar
W. (FRG) |
Kakác
B. (CZ) |
Purcell
W.P. (USA) |
Waisser
K. (CZ) |
| Dittrich
F. (GDR) |
Kier
L.B. (USA) |
Rábek
V. (CZ) |
Weichet
J. (CZ) |
| Draber
W. (FRG) |
Koller
J. (Yugoslavia) |
Redl
G. (USA) |
Wolff
M.E. (USA) |
| Drobnica
L. (CZ) |
Kollman
P.A. (USA) |
Rejholec
V. (CZ) |
Wold
S. (Sweden) |
| Druckrey
E. (FRG) |
Krivucová
M. (CZ) |
Repke
K.R.H. (GDR) |
Zahradník
R. (CZ) |
| |
|
|
Zeelen
F.J. (The Netherlands) |
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Last
Updated: June 25, 2001 |
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