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Our client, a well recognized leader in the pharmaceutical industry,
currently has the following newly created position available in their "state-of-the-art"
research facility located in the North East.
SENIOR OR PRINCIPAL SCIENTIST - COMPUTER AIDED DRUG DESIGN
This hand-on role reporting to the Head, Structural Research will provide expertise in molecular modeling to enhance lead-optimization/identification
for their multiple drug discovery programs.
DUTIES AND RESPONSIBILITIES include but are not limited to the following:
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Responsible for structure-based modeling (binding models, binding
affinities, pharmacophore searches, de novo compound design), SAR analysis, and
structure-guided library design in support of lead-optimization projects. |
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Responsible for cheminformatic analyses of hit sets, structure-based
modeling, SAR analysis, and structure-guided and/or cheminformatic-guided library
design in support of lead-identification projects. |
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Provide support to pre-screening projects through structure-based,
target-class-based, and/or cheminformatic-based selection of compound screening sets. |
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Provide new and innovative methodologies in computational biology to the
design of optimum constructs for experimental structure determination efforts. |
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Represent structural research group as a member of interdisciplinary project
teams involved in target validation, lead identification and lead optimization. |
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Maintain all appropriate notebook records for all studies assuring that
normal lab SOP requirements are adhered to. |
REQUIREMENTS: Ph.D. Computational Chemistry, Organic Chemistry or a related
disciplines with pharmaceutical/biotechnology industry experience focused on
computer-aided drug design (CADD) and demonstrable practical exposure to chemical informatics (cheminformatics). Experience working with a
variety of CADD methodologies, e.g., structure-based compound design, prediction of
compound binding affinities, prediction of compound ADME properties, compound-to-target docking, virtual screening (preferably high-throughput),
and molecular library design are required. You must have excellent oral and written, communication and presentation skills. The ability to work in a
fast-paced, goal-oriented team environment is needed. Leadership potential
is a strong plus. Familiarity with methodologies in computational biology a plus.
COMPENSATION: $95.0K - $120.0K base salary, bonus eligible, 401K, pension
plan, excellent benefits plans, full relocation.
Please forward resume/CV in confidence to:
Dean Kaplan, Kaplan Scientific
(203) 406-2314, Fax (203) 406-2315, DEAN@KAPSCI.COM, WWW.KAPSCI.COM
Last updated: March 29, 2002
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