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Computational Chemist
Goal/Objective
The candidate must be a highly motivated individual who is
able to work closely with multidisciplinary teams of chemists and biologists. The position offers the challenging opportunity to aid in the
optimization of potential insecticides through all phases of the project-from HTS to the field. The responsibilities would include data
mining, prioritization of the leads, pharmacophore generation, development of homology models, 2D and 3D
QSAR/QSAR, and the development of physico-chemical/ADME models of insecticides.
Education/Experience
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Ph.D plus 3-5 years in Computational Chemistry, or related fields
with computational experiences |
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A background in Biology, Structural Biology, or Organic Chemistry is
required |
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Ability to work effectively in a highly collaborative team-based
environment |
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Strong motivation and excellent communication skills |
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Experience in UNIX, CERIUS2 , CATALYST , SYBYL ,
MOE , or other modeling packages |
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Programming in C++ or PERL, and basic database experience required |
Major Responsibilities
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Use the necessary tools to optimize leads at all stages of a project |
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Data mining of weekly active hits from HTS |
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Prioritization of the lead compounds |
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Development of PHARMACOPHORE models |
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Homology modeling |
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Optimization of whole organism activity using the models developed in
conjunction with 2D/3D and QSPR methods. |
Contact
Richard Berger
Phone +1-267-880-1650 ext 204, E-mail officeadmin@eagle-staffing.com
Last updated: May 21, 2002
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